Marcel Olde Rikkert

Our research on the V-Time intervention against falling by elderly persons was published by the Lancet (aug 2016), and received an enormous amount of media attention. See the abstract in attatchment. Resilience in balance is improved and people fall substantially less!!

Addition of a non-immersive virtual reality component to treadmill training to reduce fall risk in older adults (V-TIME): a randomised controlled trial. Lancet 2016 Aug 11

BACKGROUND:

Age-associated motor and cognitive deficits increase the risk of falls, a major cause of morbidity and mortality. Because of the significant ramifications of falls, many interventions have been proposed, but few have aimed to prevent falls via an integrated approach targeting both motor and cognitive function. We aimed to test the hypothesis that an intervention combining treadmill training with non-immersive virtual reality (VR) to target both cognitive aspects of safe ambulation and mobility would lead to fewer falls than would treadmill training alone.

METHODS:

We carried out this randomised controlled trial at five clinical centres across five countries (Belgium, Israel, Italy, the Netherlands, and the UK). Adults aged 60-90 years with a high risk of falls based on a history of two or more falls in the 6 months before the study and with varied motor and cognitive deficits were randomly assigned by use of computer-based allocation to receive 6 weeks of either treadmill training plus VR or treadmill training alone. Randomisation was stratified by subgroups of patients (those with a history of idiopathic falls, those with mild cognitive impairment, and those with Parkinson's disease) and sex, with stratification per clinical site. Group allocation was done by a third party not involved in onsite study procedures. Both groups aimed to train three times per week for 6 weeks, with each session lasting about 45 min and structured training progression individualised to the participant's level of performance. The VR system consisted of a motion-capture camera and a computer-generated simulation projected on to a large screen, which was specifically designed to reduce fall risk in older adults by including real-life challenges such as obstacles, multiple pathways, and distracters that required continual adjustment of steps. The primary outcome was the incident rate of falls during the 6 months after the end of training, which was assessed in a modified intention-to-treat population. Safety was assessed in all patients who were assigned a treatment. This study is registered with ClinicalTrials.gov, NCT01732653.

FINDINGS:

Between Jan 6, 2013, and April 3, 2015, 302 adults were randomly assigned to either the treadmill training plus VR group (n=154) or treadmill training alone group (n=148). Data from 282 (93%) participants were included in the prespecified, modified intention-to-treat analysis. Before training, the incident rate of falls was similar in both groups (10·7 [SD 35·6] falls per 6 months for treadmill training alone vs 11·9 [39·5] falls per 6 months for treadmill training plus VR). In the 6 months after training, the incident rate was significantly lower in the treadmill training plus VR group than it had been before training (6·00 [95% CI 4·36-8·25] falls per 6 months; p<0·0001 vs before training), whereas the incident rate did not decrease significantly in the treadmill training alone group (8·27 [5·55-12·31] falls per 6 months; p=0·49). 6 months after the end of training, the incident rate of falls was also significantly lower in the treadmill training plus VR group than in the treadmill training group (incident rate ratio 0·58, 95% CI 0·36-0·96; p=0·033). No serious training-related adverse events occurred.

INTERPRETATION:

In a diverse group of older adults at high

Cover of my recently published books: "I am demented" and "Staying Young & Getting Older" Both books are printed in Dutch and were excellently received in the lay press.

Marcel Olde Rikkert

This website will give you concise information on:

Who am I?

What did I do so far?


- Patient care
- Research & development
-Teaching
-
Management

What can I do for you?

Latest news:
Three papers on loneliness among older persons in the newspapers. We contributed to this important issue in interviews with radio and newspapers (e.g. NRC Saturday aug 27).

The multicentre research on the V-Time intervention we carried out together with leading centre Tel Aviv, against falling by elderly persons, was published by the Lancet (aug 2016), and received an enormous amount of media attention. See the abstract in attatchment.

April 2016: Book: "Ik ben dement" . Sincere letters written by persons suffering from dementia to their fellow-patients.

Newspapers commented in April: Excellent and intriguing disclosure of how people with dementia view their own life, and recommend active life style to other persons with dementia. In "Pauw" (Television two persons with dementia were interviewed, and gave a hope giving view in their personal lives.

Book: "Jong Blijven & Oud Worden",
published by Thoeris A'dam May 2015.

De Volkskrant commented (May 23, 2015):

"Olde Rikkert pakt het onderwerp op ludieke wijze aan in een boek dat de vaart erin houdt" "Hij kiest voor fijne invalshoeken: van doping in bed tot de kunst van het leren verliezen" (Ellen de Visser)

Zie: www.facebook.com/OudNieuwsFestival a festival report on aging, against ageism, developed together with artist Sven Hoekstra and ProjectYou.

May 2015, Neurology published our trial on THC (Namisol), which resulted also in important societal impact in lay-press.

 

Dec 3rd 2014: dr Aisha van Meel-van den Abeelen, PhD student of our department received a cum laude for her thesis & defense of her groundbreaking research work on cerebrovascular autoregulation.

June 2014: our interneship was granted the INTERNSHIP OF THE YEAR PRIZE, which evidences our dedication to teaching.

20 Dec 2013: I got appointed as one of the first seven Principal Clinicians of the Radboud University Nijmegen Medical Centre who should lead innovation in patient care, and patient care related research!

 

 

 

Image of the employees of the dept Geriatrics who were present at the 25th anniversary ceremony of the department at 29th sept 2013.

Lay press on THC for dementia related neuropsychiatric symptoms

 

Radboudumc in het nieuws

 

 

CANNABIS-EXTRACT   PILLS 'NOT EFFECTIVE' FOR DEMENTIA SYMPTOMS

UK Government News, May 14, 2015 Thursday 12:28 PM EST

LONDON, May 14 -- National Health Service issued the following   health news: "Cannabis pills 'do not help dementia sufferers',"   reports The Daily Telegraph. Previous research suggested one of the active   ingredients in cannabis - tetrahydrocannabinol...

 

 

Montana:   Cannabis might not cause psychosis, but it doesn't cure dementia

European Union News, May 14, 2015 Thursday

Clear Cannabis law Reform UK has issued the following news   release: Reports have started flooding in that research into the effects of   cannabis on dementia sufferers is deemed to be ineffective, the same week   that research suggest that cannabis mi...

 

 

Cannabis-extract   pills 'not effective' for dementia symptoms

European Union News, May 14, 2015 Thursday

Clear Cannabis law Reform UK has issued the following news   release: "Cannabis pills 'do not help dementia sufferers'," reports   The Daily Telegraph. Previous research suggested one of the active   ingredients in cannabis – tetrahydrocannabinol (THC)...

 

 

CANNABIS-EXTRACT   PILLS FOR DEMENTIA SHOW POOR RESULTS

States News Service, May 14, 2015 Thursday

The following information was released by the National Health   Service (NHS) of the United Kingdom: "Cannabis pills 'do not help   dementia sufferers'," reports The Daily Telegraph. Previous research   suggested one of the active ingredients in cannabis...

 

 

Nieuw   medicijn polycysteuze leverziekten

ZIEKENHUISNL, 2015-05-15T00:26:20+01:00

Nieuw medicijn polycysteuze leverziekten Nieuw medicijn   polycysteuze leverziekten vrijdag 15 mei 2015 | Bron: Radboudumc.nl Er is een   nieuwe behandeling mogelijk van polycysteuze leverziekten  met   medicijnen, in plaats van met een operatie. Tom ...

 

 

Pot   Pill Doesn't Lessen Dementia Symptoms (CME /CE)

MEDPAGE, 2015-05-14T21:51:33+01:00

A low-dose "pot pill" wasn't effective at mitigating symptoms of dementia, researchers reported. In a randomized controlled trial, patients who were taking either placebo or oral tetrahydrocannabinol (THC, Namisol) had similar reductions in neuropsyc..

 

 

Medical   marijuana might not help ease symptoms of dementia

THE VERGE, 2015-05-14T03:17:56+01:00

Science Medical marijuana might not help ease symptoms of   dementia By Adi Robertson on May 13, 2015 07:13 pm @thedextriarchy 6 Of all   the reasons to reform medical marijuana laws, one of them is a little   counter-intuitive:  we don't actually kno..

 

 

Cannabis-extract   pills 'not effective' for dementia symptoms

NATIONAL HEALTH SERVICE, 2015-05-14T20:40:59+01:00

THC can trigger both pleasant and unpleasant sensations   "Cannabis pills 'do not help dementia sufferers'," reports The   Daily Telegraph. Previous research suggested one of the active ingredients in   cannabis – tetrahydrocannabinol (THC)

 

 

DWDD   university ‘Het Brein’ – deel 3

KENNISLINK, 2015-05-14T17:55:27+01:00

donderdag 14 mei 2015 Dit is een publicatie van Kennislink DWDD   University ‘Het Brein’ – deel 3 Laat je bijspijkeren over je hersenen door   professor Erik Scherder ‘Waar zit de aanknop van ons brein? Wat gebeurt er   precies bij een coma?’ Deze vrag

 

 

Medical   Marijuana Pill May Not Be Effective in Treating Behavioral Symptoms of   Dementia

Targeted News Service, May 13, 2015 Wednesday 3:40 AM EST

The American Academy of Neurology issued the following news   release: A new study suggests that medical marijuana pills may not help treat   behavioral symptoms of dementia, such as aggression, pacing and wandering.   The research is published in the May...

 

 

Danville   Regional Health System; 'Medical Marijuana' Pill Falls Short in Dementia   Study 13 May 2015

News Bites - Private Companies, May 14, 2015 Thursday

WEDNESDAY, May 13, 2015 (HealthDay News) -- So-called medical   marijuana pills may not ease the common behavioral symptoms that affect   people with dementia, a small study suggests. In a trial of 50 dementia   patients, researchers found that pills con...

 

 

Stoughton   Hospital: 'Medical Marijuana' Pill Falls Short in Dementia Study 13 May 2015

News Bites - Private Companies, May 14, 2015 Thursday

So-called medical marijuana pills may not ease the common   behavioral symptoms that affect people with dementia, a small study suggests.   In a trial of 50 dementia patients, researchers found that pills containing   the main active ingredient in mariju...

 

 

Dementia:   cannabis is no help

The Daily Telegraph (London), May 14, 2015 Thursday

CANNABIS pills may not be effective in treating the behavioural   symptoms of dementia, suggests new research. Symptoms such as aggression,   pacing and wandering are not helped by medical marijuana pills, according to   research.

 

 

Oud   nieuws festival in De lindenberg

De Nijmegenaar, 16 mei 2015 zaterdag

Oud nieuws festival in De lindenberg Nijmegen - In de Lindenberg   vindt op 21 mei het ‘Oud Nieuws’ festival plaats. Kunstenaars en deskundigen   presenteren er voor jonge mensen de veelzijdigheid van ouderdom. Onder meer   singer-songwriter Michael Prins...

 

 

met   hart en ziel voor marikenloop

De Nijmegenaar, 16 mei 2015 zaterdag

Nog even traint Laurène André alleen in het Goffertpark. Zondag   start zij samen met moeder en zus aan de dertiende editie van De Marikenloop.   foto Jimmy Israël ‘Ik heb aan alle edi...

 

 

MEDICAL   MARIJUANA PILL MAY NOT BE EFFECTIVE IN TREATING BEHAVIORAL SYMPTOMS OF   DEMENTIA

States News Service, May 13, 2015 Wednesday

The following information was released by the American Academy   of Neurology (AAN): A new study suggests that medical marijuana pills may not   help treat behavioral symptoms of dementia, such as aggression, pacing and   wandering. The research is publi...

 

 

Medical   Marijuana Pill Falls Short: Dementia Study

SCIENCE BLOGS, 2015-05-14T03:41:46+01:00

Medical Marijuana Pill Falls Short: Dementia Study Researchers had hoped to ease anxiety, agitation and wandering WebMD News from HealthDay By Amy Norton HealthDay Reporter WEDNESDAY, May 13, 2015 (HealthDay News) -- So-called medical marijuana pills...

 

 

Cannabis   pills 'do not help dementia sufferers'; It had been thought chemicals   contained within can...

telegraph.co.uk, May 13, 2015 Wednesday 9:23 PM GMT

Cannabis pills may not be effective in treating the behavioural   symptoms of dementia, new research suggests. The study suggests that medical   marijuana pills may not help treat dementia symptoms such as aggression,   pacing and wandering.

 

 

Geen   alcohol tot achttien?

EOS WETENSCHAP, 2015-05-13T12:49:06+01:00

Geen alcohol tot achttien? Artikel | 13 mei, 2015 - 9:52 Steeds   meer jongeren doen aan 'bingedrinken’, met potentieel kwalijke gevolgen -   vooral voor meisjes .   De cijfers over het drinkgedrag komen uit een   nieuwe studie die de Organisati..

 

 

Festival   biedt ‘jong’ frisse kijk op ‘oud’

De Brug Nijmegen, 13 mei 2015 woensdag

‘ouderen zijn allesbehalve ‘oud nieuws’ Festival biedt ‘jong’   frisse kijk op ‘oud’ ‘Oud Nieuws’ festival in De Lindenberg