Our innovation and research


Marcel Olde Rikkert is Clinician-Innovator and Principal Investigator at the Radboud University Medical Centre and his research overall focuses on innovation and evaluation of complex interventions in frail elderly, with special focus on frailty and cognitive decline. On this topic his group carried out several randomized trials: on dementia care, nutrition, occupational therapy, and guidance by general practitioners versus medical specialists in dementia patients (see BMJ 2012/2013). We also have devloped a special interest in tipping poinst in geriatrics,  e-health for frail elderly, and developed:

-Health and welfare poratl for drail elderly: ZWIP. See www.ZWIP.NL

-Brain aging monitor, to guide life style and brain aging by self management. See: www.brainagingmonitor.nl 

-See also our EASYcare innovation video at We & our patients

R&D team

The research is carried out in close collaboration with the other (j) PI’s, researchers and PhD students, who together form the geriatric department's research teams. Key players are:
Dr Jurgen Claassen, geriatrician, JPI
Dr René Melis, MD epidemiologist and senior researcher, PI
Prof dr Roy Kessels, neuropsychologist. PI.

And other researchers/innovators such as:
Dr. Olga Meulenbroek, ass porofessor at the Alzheimer Centre;
Dr. Dannie vd Brink and Dr Jennifer Lutomski in the national database study and drs Teun Aalbers in the healthy brain aging monitor (www.brainagingmonitor.nl);
Dr. Li Qin, at the national databases for dementia and the Dutch Programme for Health Care in frail elderly (NPO) programme;
Dr. Arenda Dado-Van beek, as post doc and trainee in geriatrics, involved in developing cerberal perfusion measurements.
Dr. Miriam Reelick, is ass professor in the V-Time study on prevention of falls by virtual reality and exercise.
Dr. Joep Lagro, staff geriatrician and PL and researcher in education and integrated sytems/ homestasis.
Dr Yvonne Schoon,staff geriatrician, specialised in falls and movement disorders in the elderly.
Dr Didy Jacobse, staff geriatrician, and specialised in EPIC support and project leader EASYcare in Hospital.
Dr. Marianne v Iersel, innovation in training of young geriatricians.
Mrs Annemie Diepstraten, senior clinician and specialised in quality management, pharmacotherapy, and training of medical interns.
Mrs William van Aalst, physician assistant and very well equipped and experienced in guiding dementia patients through care and research projects (clinical study leader in Nilvad and several other trials).

 International networks

 Further, we work in close collaboration with researchers from other departments of the RUNMC (e.g. IQ Health Care prof G Westert, prof dr Pim Assendelft, primary care; dr Eddy Adang Health Evidence, and others).
Our international collaboration is strong with UK for example on EASYcare (eg prof John Gladman, and prof Ian Philp in Nottingham and Hull), and the USA (e.g. Prof Chris Callahan, Indianapolis, dr July Bynum Dartmouth, prof Stephanie Studenski, Pittsburgh and prof Rosanne Leipzig, New York).

We also collaborate in the European Alzheimer Disiease consortium (EADC, see www.EADCinfo, the European Dementia Consensus Network (EDCON), the International Dementia Alliance (IDEAL), and are reference site for the IAGG, and the EU in the Healthy and active aging programme.

Our current research focuses on two main topics:

1. Dementia and related problems

2. Frailty in old age

Dementia related research questions:
-Prevention: How can health life style contribute best to healthy brain aging?
-Health sevices research: What are the best interventions for subjects with cognitive decline? How can AlzheimerNet realize added value for patients, cost-effectiveness for society and better education for professionals in dementia care?
-Diagnostics: What do biomarkers add to current diagnostics of dementia in old age? What added value does early diagnosis deliver for the older persons and their proxies?
-Etiology: How does comorbidity contribute to cognitive decline in old age?

Frailty related questions:

-Etiology: What contributes to frailty in old age?
-Health services research: How can we best supply hospitals with save and afficient care for the frail elderly? How can we de-fragmentize health care?
-Diagnostics: How can we best test frailty in primary and secondary care?

Research Tools:
-Epidemiological research in large cross-sectional and longitudinal cohorts
-Parient Reported Outcome measures in dementia and frailty.
-DashBoard for continuous measurement of added value in health care for frail older subjects and dementia care.
-Cerebrovscaular perfusion measurements/imaging (NIRS, ASL, TCD, RR measurements)
-Comorbidity and frailty assessments (gait speed, gait analysis, balance, falls assessment)
-Neuropsychological testing (own computerized test batteries).
-Innovative interventions (such as the Care and Welfare Information Portal, see www.zwip.nl)

Research institutes:
Radboud Alzheimer Centre (see www.RadboudAlzheimerCentre)
Donders Institure for Brain, Cognition, and Behaviour (see: http://www.ru.nl/donders/)
Nijmegen Centre for Evidence Based Practice (NCEBP)  (http://www.umcn.nl/RESEARCH/RESEARCHINSTITUTES/NCEBP/Pages/default.aspx)

Recent publications:
More than 300 peer reviewed publications
(see:http://www.researcherid.com/rid/D-9773-2012 )

3 most recent top-publications:

1. Cholinesterase inhibitors and add-on nutritional supplements in Alzheimer's disease A systematic review of randomized controlled trials
Rijpma, A.; Meulenbroek, O.; Rikkert, M. G. M. Olde

2. Olde Rikkert MG, Melis R. Nonagenarians challenge predictions of cognitive decline. Lancet. 2013 Jul 10. doi:pii: S0140-6736(13)61220

3. Clegg A, Young J, Iliffe S, Olde Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013 Mar 2;381(9868):752-62.