Our innovation and research

RESILIENCE AND COMPLEXITY IN COMPLEX DISEASES OF AGING

My scientific work as geriatrician has scientific impact, as illustrated by the still growing number of citations (2,782 citations in 2019; Google Scholar, check May 5th 2020). In total, I published over 450 scientific papers that have been cited 11,275 times, yielding an H-index of 46/58 (WoS/G Scholar; i10: 206). Around 35% of my papers are in the top 10% of my field, and ± 65% of my work was published in the top 25% of medical journals. This ranks me high as influential scientists in Geriatrics. My papers include publications in the British Medical Journal, The Lancet, and 43 papers in the top 10 journals on Aging or Neurosciences: Lancet Neurology, Proceedings of the National Academy of Sciences of America; JAMA Neurology, Neurology, Alzheimer & Dementia, J Alz Dis and Geriatrics & Gerontology, J Am Med Dir, Age Res Rev, J Gerontol Biol-Med in Age Ageing, and 4 in several in the J American Geriatrics Soc. I have also contributed chapters to international textbooks, such as the Oxford Textbook of Geriatrics (2017), the Oxford Alzheimer’s Disease Textbook (2017, 2013 & 2016, respectively), and the Oxford Univ Press Handbook of Complex Systems and Public Health (2020).
 

The geriatric research group also carried out several randomized trials and practice evaluations of which the latest were very innovative and both published in top journals:

1. Gijzel S and Olde Rikkert M/ Melis R. Measurement of Dynamical Resilience Indicators Improves the Prediction of Recovery Following Hospitalization in Older Adults. JAMDA 2020 Apr;21(4):525-530.e4. doi: 10.1016/j.jamda.2019.10.011

2. The V-time study, in which a virtual reality intervention lowers the likleihood of falls in older patients with low resilience in gait and posture. See Lancet Aug 11, 2016.

3. The Namisol study, on cannabis for behavioral disturbances in Alzheimer's, which was published in Neurology (2015). This study showed no overall effect, but points at the fact that higher dose cannabis may be applied in future research on dementia care, as the lower doses were completly safe.

Other innovations by his research group:

-DementiaNet Innovation: www.dementienet.com

-  :  Spel innovatie met GSL en Dela

-Geriatrix spel   serious game voor medisch studenten ter training in persoonsgerichte zorg

 

R&D team

The research is carried out in close collaboration with the other (j) PI’s, researchers and PhD students, who together form the geriatric department's research teams. Key players are:
Dr Jurgen Claassen, geriatrician, PI
Dr René Melis, MD epidemiologist and senior researcher, PI
Prof dr Roy Kessels, neuropsychologist.
Dr Geeske Peeters, senior researcher
Dr Marit Sanders, technical physician;
Dr Marieke Perry, family practitioner
Dr Jerrald Rector, Movement and data scientist
Dr Rianne de Heus, post doc
Dr MInke Nieuwboer, senior Consultant/ Nursing scientist

And other researchers/innovators such as:
Dr Marit Sanders coordinator of the Radboudumc Alzheimer Centre;
Karin Habets, data manager national database study TOPICS-MDS, see www.TOPICS-MDS.eu
developed as national databases for dementia and the Dutch Programme for Health Care in frail elderly (NPO) programme;

Dr Dieneke van Asselt, heads the training of geriatric residents, and is researchers in interprofesional training.
Dr. Marianne v Iersel, staff geriatrician, junior Principal Lecturer and researcher in education.
Dr Yvonne Schoon,staff geriatrician, heads the emergency department of the Radboudumc as well, and is specialised in falls and movement disorders in the elderly.
Dr Didy Jacobse, staff geriatrician, internist specialised in older persons, and specialised in EPIC support and project leader EASYcare in Hospital.
Drs Carolien Benraad, senior clinician and specialised in training residents and in research on effectiveness of geriatrics in psychiatry for old age quality management.
Drs David Jansen geriatrician and clinical pharmacologist.
Drs Anne Verstraten, chef of outpatient clinics;
Drs Roderick Kriekaart, staff geriatrician in SMK, peri operative guidance of frail older patients.
Mrs William van Aalst & Maartje v Beek, physician assistants and very well equipped and experienced in guiding dementia patients through care and research projects (clinical study leader in Nilvad and several other trials).

 International networks

Further, we work in close collaboration with researchers from other departments of the Radboudumc (e.g. Prof Judith Prins, medical psychology, IQ Health Care prof G Westert, prof dr Pim Assendelft, primary care; dr Eddy Adang Health Evidence, and many others).

We actively collaborate in the SPARCS network on tipping point research with prof Marten Scheffer.http://www.sparcs-center.org/about-us/staff-contacts/marten-scheffer.html

Our international collaboration is strong with UK for example on EASYcare (eg prof John Gladman, and prof Ian Philp in Nottingham and Hull), and the USA (e.g. Prof Heather Whitson at Duke University; Prof Chris Callahan, Indianapolis, dr July Bynum Dartmouth, prof Stephanie Studenski, Pittsburgh and prof Rosanne Leipzig, New York).

We also collaborate in the European Alzheimer Disiease consortium (EADC, see www.EADCinfo, the European Dementia Consensus Network (EDCON), the International Dementia Alliance (IDEAL), and are reference site for the IAGG, and the EU in the Healthy and active aging programme.

Our current research focuses on two main topics:

1. Complexity and Resilience in older persons:

From the perspective of complexity science and systems dyanmics we want to improve diagnosing and forecasting Tipping Points and prevent deterioration in health by better guidance.
Our vision is to creat a personal digitalized guidance, based on careful listening and following individual older persons along their disease trajectories.

2. Dementia and related problems

Dementia related research questions:
-Prevention: How can health life style contribute best to healthy brain aging?
-Health sevices research: What are the best interventions for subjects with cognitive decline? How can AlzheimerNet realize added value for patients, cost-effectiveness for society and better education for professionals in dementia care?
-Diagnostics: What do biomarkers add to current diagnostics of dementia in old age? What added value does early diagnosis deliver for the older persons and their proxies?
-Etiology: How does comorbidity contribute to cognitive decline in old age?
 
Research Tools:
-Epidemiological research and sophisticated modeling in large cross-sectional and longitudinal cohorts, and in indivdual time series.

-Time series analyses wth smart sensors and in our hemodynamics lab.

-Parient Reported Outcome measures in Tipping Points, related to dementia and other geriatric syndromes.

-DashBoard for continuous measurement of added value in health care for frail older subjects and dementia care.
-Cerebrovscaular perfusion measurements/imaging (NIRS, ASL, TCD, RR measurements)
-Comorbidity and frailty assessments (gait speed, gait analysis, balance, falls assessment)
-Neuropsychological testing (own computerized test batteries).
-Innovative interventions (such as the Care and Welfare Information Portal, see www.zwip.nl)

Research institutes:
Radboudumc Alzheimer Centre  ate the Donders Institure for Brain, Cognition, and Behaviour (see: http://www.ru.nl/donders/)
Radboud Institute for Health Sciences (RIHS)

Recent publications:
More than 400 peer reviewed publications . H-index: 58
(see:http://www.researcherid.com/rid/D-9773-2012 )

3 mst cited publications:

1. Clegg A, Young J, Iliffe S, Olde Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013 Mar 2;381(9868):752-62. Citations: 3500

2. Lancet. 2016 Aug 11. Addition of a non-immersive virtual reality component to treadmill training to reduce fall risk in older adults (V-TIME): a randomised controlled trial.

2. Tetrahydrocannabinol for neuropsychiatric symptoms in dementia: A randomized controlled trial. van den Elsen GA, Ahmed AI, Verkes RJ, Kramers C, Feuth T, Rosenberg PB, van der Marck MA, Olde Rikkert MG. Neurology. 2015 Jun 9;84(23):2338-46.